2023 Protective effect of IAXO-102 on renal ischemia-reperfusion injury in rats

Protective effect of IAXO-102 on renal ischemia-reperfusion injury in rats Yahiya Ibrahim Yahiya, Najah Rayish Hadi, Ahmed Abu Raghif, Noor Ghaffar Said Al Habooby Abstract Ischemia/reperfusion injury (IRI) is a common cause of kidney damage, characterized by oxidative stress and inflammation. In this study, we investigated the potential protective effects of IAXO-102, a

Read More

2023 Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages

Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages Charys Palmer, Fabio A Facchini, Richard PO Jones, Frank Neumann, Francesco Peri, and Grisha Pirianov Abstract TLRs, including TLR4, play a crucial role in inflammatory-based diseases, and TLR4 has been identified as a therapeutic target for pharmacological intervention. In previous studies, we investigated the potential of

Read More

2023 A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice

A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice Deebika Balu, Ana C. Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu & Leon M. Tai Abstract Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is greater in

Read More

2017 TLR4-Mediated Placental Pathology and Pregnancy Outcome…

TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria  Sci Rep. 7:8623 (2017) Barboza R1, Lima FA2, Reis AS2, Murillo OJ2, Peixoto EPM2, Bandeira CL2, Fotoran WL2, Sardinha LR3, Wunderlich G2, Bevilacqua E4, Lima MRD5, Alvarez JM5, Costa FTM6, Gonçalves LA2, Epiphanio S7, Marinho CRF8. Abstract  Malaria-associated pregnancy has a

Read More

2016 Synthetic and natural small molecule TLR4 antagonists…

Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model (2016) Pharmacol Res. 103:180 (2016) De Paola M1, Sestito SE2, Mariani A3, Memo C3, Fanelli R3, Freschi M4, Bendotti C4, Calabrese V2, Peri F5. 1 Department of Environmental Health Sciences, IRCCS-Istituto di Ricerche Farmacologiche “Mario

Read More

2015 A novel small molecule TLR4 antagonist (IAXO-102)…

A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development (2015) Atherosclerosis. 242:563 (2015) Huggins C1, Pearce S1, Peri F2, Neumann F3, Cockerill G1, Pirianov G4. 1 Institute of Cardiovascular Sciences and Cell Biology, St Georges University of London, UK 2 Department of

Read More