Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance J Neural Eng. 15:025002 (2018) Hermann JK1, Ravikumar M, Shoffstall AJ, Ereifej ES, Kovach KM, Chang J, Soffer A, Wong C, Srivastava V, Smith P, Protasiewicz G, Jiang J, Selkirk SM, Miller RH, Sidik
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria Sci Rep. 7:8623 (2017) Barboza R1, Lima FA2, Reis AS2, Murillo OJ2, Peixoto EPM2, Bandeira CL2, Fotoran WL2, Sardinha LR3, Wunderlich G2, Bevilacqua E4, Lima MRD5, Alvarez JM5, Costa FTM6, Gonçalves LA2, Epiphanio S7, Marinho CRF8. Abstract Malaria-associated pregnancy has a
Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice Mol Neurobiol. 54:6624-6633 (2017) Kawakita F1, Fujimoto M1, Liu L1, Nakano F1, Nakatsuka Y1, Suzuki H2. Abstract Toll-like receptor 4 (TLR4) signaling may play a crucial role in the occurrence of cerebral vasospasm after subarachnoid hemorrhage
Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model (2016) Pharmacol Res. 103:180 (2016) De Paola M1, Sestito SE2, Mariani A3, Memo C3, Fanelli R3, Freschi M4, Bendotti C4, Calabrese V2, Peri F5. 1 Department of Environmental Health Sciences, IRCCS-Istituto di Ricerche Farmacologiche “Mario
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development (2015) Atherosclerosis. 242:563 (2015) Huggins C1, Pearce S1, Peri F2, Neumann F3, Cockerill G1, Pirianov G4. 1 Institute of Cardiovascular Sciences and Cell Biology, St Georges University of London, UK 2 Department of
Toll like Receptor 4 antagonist prevents acetaminophen induced acute liver failure in mice: A novel therapeutic strategy Key role for TLR4 in ALF (April 2012) EASL, Barcelona, Spain N. Shah, D. Dhar, M. Jover, N.A. Davies, R.P. Mookerjee, R. Jalan UCL, Institute of Hepatology, London, UK Background and aim Without