Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance J Neural Eng. 15:025002 (2018) Hermann JK1, Ravikumar M, Shoffstall AJ, Ereifej ES, Kovach KM, Chang J, Soffer A,
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria Sci Rep. 7:8623 (2017) Barboza R1, Lima FA2, Reis AS2, Murillo OJ2, Peixoto EPM2, Bandeira CL2, Fotoran WL2, Sardinha LR3, Wunderlich G2, Bevilacqua E4, Lima MRD5,
Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice Mol Neurobiol. 54:6624-6633 (2017) Kawakita F1, Fujimoto M1, Liu L1, Nakano F1, Nakatsuka Y1, Suzuki H2. Abstract Toll-like receptor 4 (TLR4)
Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model (2016) Pharmacol Res. 103:180 (2016) De Paola M1, Sestito SE2, Mariani A3, Memo C3, Fanelli R3, Freschi M4, Bendotti
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development (2015) Atherosclerosis. 242:563 (2015) Huggins C1, Pearce S1, Peri F2, Neumann F3, Cockerill G1, Pirianov G4.
Toll like Receptor 4 antagonist prevents acetaminophen induced acute liver failure in mice: A novel therapeutic strategy Key role for TLR4 in ALF (April 2012) EASL, Barcelona, Spain N. Shah, D. Dhar, M. Jover, N.A.